The Naismith lab at St Andrews has been active in structural biology since 1992 and has published 150 papers. They have determined the structural basis of gating in the mechanosensitive ion channel, the structural basis of carbohydrate export and contribution to bacterial antibiotic resistance of porin mutation.
Role: Structure determination of integral membrane proteins and measurement of conformational change.
Key facilities and infrastructure: expression, purification and crystallisation of integral membrane proteins. The use PELDOR spectroscopy to measure changes in distances between secondary structural elements. The lab is equipped with state of the art crystallisation and data collection equipment (including robotics). It has extensive molecular biology facilities.