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cropped-figura-report-mathias11.pngThe discovery and development of novel antibacterial agents is a scientifically challenging, long term endeavor. Specifically, the discovery of new agents to treat resistant Gram-negative infections generally relies on developing agents which can penetrate at least one, often both the membranes of the Gram-negative cellular envelope. This envelope, comprised of both an outer and inner membrane, which have significantly different properties, provides Gram negative bacteria with an excellent physical barrier to antibacterial agents.

The ITN project ” Molecular Basis of Antibiotic Translocation  ” aims to improve our overall understanding of how small molecules penetrate into and are effluxed out of Gram-negative bacteria in order to allow better rational drug design for the discovery of new antibiotics which could be used to treat severe, multi-resistant Gram-negative infections.

We expect that combining microbiology, structural biology and all-atom modeling will contribute to understand the permeability of small molecules across the Gram-negative bacteria.

The following are the ongoing projects at Partners institutions:

Jacobs University 

University of Cagliari

Goethe University 

University of Saint Andrews 

Newcastle University 

IME Fraunhofer Institut

Aix Marseille Université

University of Basel

Nanion Technologies

BioVersys AG