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2017

Trebosc, Vet al. “Reversion of Antibiotic Resistance in Mycobacterium tubercolosis by spiroisoxazoline SMARt-420″. Science 2017. Mar 2017 Vol. 355, Issue 6330, pp. 1206-1211 doi: 10.1126/science.aag1006

A. Gilardi, S.P. Bhamidimarri, M. Broenstrup, U. Bilitewski, R.K.R. Marreddy, K.M. Pos, L. Benier, P. Gribbon, M. Winterhalter, B. Windshuegel. “Biophysical characterization of E. coli TolC interaction with the known blocker hexaamminecobalt”.Biochim Biophys Acta. 2017 Nov;1861(11 Pt A):2702-2709. Epub 2017 Jul 23. doi: 10.1016/j.bbagen.2017.07.014

Ramaswamy, V. K., Vargiu, A.V., Malloci, G., Dreier, J. G., & Ruggerone, P. ”Molecular rationale behind the differential substrate specificity of bacterial RND multi-drug transporters”.  Scientific Reports 7, Article number: 8075(2017doi:10.1038/s41598-017-08747-8

Harsha Bajaj, Silvia Acosta-Gutiérrez, Igor Bodrenko, Giuliano Malloci, Mariano Andrea Scorciapino, Mathias Winterhalter and Matteo Ceccarelli. “Bacterial Outer Membrane Porins as Electrostatic Nanosieves: exploring transport rules of small polar molecules”. ACS Nano. 2017 Jun 27;11(6):5465-5473. Epub 2017 May 12. doi: 10.1021/acsnano.6b08613

Igor V. Bodrenko, Jiajun Wang,Samuele Salis, Mathias Winterhalter, and Matteo Ceccarelli (2017). “Sensing Single Molecule Penetration into Nanopores: Pushing the Time Resolution to the Diffusion Limit”. ACS Sens. 2017 Aug 25;2(8):1184-1190. Epub 2017 Jul 28. doi: 10.1021/acssensors.7b00311

Amy J. Glenwright, Karunakar R. Pothula, Satya P. Bhamidimarri, Dror S. Chorev, Arnaud Baslé  Susan J. Firbank, Hongjun Zheng, Carol V. Robinson, Mathias Winterhalter,Ulrich Kleinekathöfer, David N. Bolam, Bert van den Berg. “Structural basis for nutrient acquisition by dominant members of the human gut microbiota.”Nature. 2017 Jan 19; 541(7637): 407–411. Published online 2017 Jan 11. doi:  10.1038/nature20828.

Mariano Andrea Scorciapino, Silvia Acosta-Gutiérrez, Dehbia Benkerrou, Tommaso D’Agostino, Giuliano Malloci, Susruta Samanta, Igor Bodrenko andMatteo Ceccarelli“Rationalizing the permeation of polar antibiotics into Gram-negative bacteria.” J Phys Condens Matter. 2017 Mar 22;29(11):113001. Epub 2017 Feb 3. doi: 10.1088/1361-648X/aa543b

Cacciotto, P., Ramaswamy, V. K., Malloci, G., Ruggerone, P., & Vargiu, A. V. “Molecular modeling of multi-drug properties of RND transporters”. Bacterial Multidrug Exporters of the series Methods in Molecular Biology” Ed.  Yamaguchi A. (Springer Verlag, Heidelberg, New York, 2017) (In Press)

Ramaswamy, V.K., Cacciotto P, Malloci G, Vargiu AV, Ruggerone P. “Computational modeling of efflux pumps and their inhibitors”.  Essays Biochem. 2017 Mar 3;61(1):141-156. Print 2017 Feb 28. doi: 10.1042/EBC20160065

2016

Trebosc, Vet al. “A Novel Genome-Editing Platform for Drug-Resistant Acinetobacter baumannii Reveals an AdeR-Unrelated Tigecycline Resistance Mechanism”. Antimicrob Agents Chemother. 2016 Nov 21;60(12):7263-7271. Print 2016 Dec.

Ramaswamy, V. K., Cacciotto, P., Malloci, G., Ruggerone, P., & Vargiu, A. V. “Multidrug efflux pumps and their inhibitors characterized by computational modeling”. In book: Efflux-Mediated Antimicrobial Resistance in Bacteria, Chapter: 30, Publisher: Springer International Publishing, Editors: Xian-Zhi Li, Christopher A. Elkins, Helen I. Zgurskaya, pp.797-831 doi: 10.1007/978-3-319-39658-3_30

Mariano Andrea Scorciapino, Tommaso D’Agostino, Silvia Acosta-Gutiérrez, Giuliano Malloci, Igor Bodrenko and Matteo Ceccarelli. “Exploiting the porin pathway for polar compound delivery into Gram-negative bacteria”. Future Med Chem. 2016 Jun;8(10):1047-62. Epub 2016 Jun 15. doi: 10.4155/fmc-2016-0038

Gopfrich, K., Li, C.Y., Ricci, M., Bhamidimarri, S.P., Yoo, J., Gyenes, B., Ohmann, A., Winterhalter, M., Aksimentiev, A., Keyser. “Large-Conductance Transmembrane Porin Made from DNA Origami”  ACS Nano201610 (9), pp 8207–8214 doi10.1021/acsnano.6b03759

Wang, J., Masi, M., Bajaj, H., Kreir, M., Winterhalter, M., & Fertig, N. (2016). “Molecular Bases Basis of Antibiotic Translocation Across Outer Membrane Porins of Enterobacter Aerogenes“. Biophysical JournalVolume 110, Issue 3, Supplement 1, p544a, 16 February 2016. http://dx.doi.org/10.1016/j.bpj.2015.11.2913

Gopfrich, K., Li, C.Y., Mames, I., Bhamidimarri, S.P., Ricci, M., Yoo, J., Mames, A., Ohmann, A., Winterhalter, M., Stulz, E., Aksimentiev, A., Keyser. “Ion Channels Made from a Single Membrane-Spanning DNA Duplex” Nano Lett.201616 (7), pp 4665–4669 doi: 10.1021/acs.nanolett.6b02039

Bhamidimarri, S.P., Prajapati, J.D., van den Berg, B., Winterhalter, M., Kleinekathofer, U. “Role of Electroosmosis in the Permeation of Neutral Molecules: CymA and Cyclodextrin as an Example”Biophys J. 2016 Feb 2;110(3):600-611. doi: 10.1016/j.bpj.2015.12.027

Zahn, M., Bhamidimarri, S.P., Baslé, A., Winterhalter, M., van den Berg, B. “Structural Insights into Outer Membrane Permeability of Acinetobacter baumannii”Structure. 2016 Feb 2;24(2):221-31. Epub 2016 Jan 21. doi: 10.1016/j.str.2015.12.009

Luana G M Ferrara, Gregor D Wallat, Lucile Moynié, Naresh N Dhanasekar, Soumeya Aliouane, Silvia Acosta-Gutiérrez, Jean-Marie Pagés, Jean-Michel Bolla, Mathias WinterhalterMatteo Ceccarelli, James H Naismith. “MOMP from Campylobacter jejuni is a trimer of 18 stranded β-barrel monomers with a Ca2+ ion bound at the constriction zone”.  J Mol Biol. 2016 Nov 6;428(22):4528-4543. Epub 2016 Sep 30. doi: 10.1016/j.jmb.2016.09.021

Silvia Acosta-Gutiérrez, Igor Bodrenko, Mariano Andrea Scorciapino and Matteo Ceccarelli“Macroscopic electric field inside water-filled biological nanopores”.  Phys Chem Chem Phys. 2016 Apr 7;18(13):8855-64. doi: 10.1039/c5cp07902k.

Wanatchaporn Arunmanee, Monisha Pathania, Solovyova AS, Le Brun AP, Ridley H, Baslé A, van den Berg B, Lakey JH. “Gram-negative trimeric porins have specific LPS binding sites that are essential for porin biogenesis.” Proc Natl Acad Sci U S A. 2016 Aug 23;113(34):E5034-43. Epub 2016 Aug 4. doi: 10.1073/pnas.1602382113

2015

Klingler FM, Wichelhaus TA, Frank D, Cuesta-Bernal J, El-Delik J, Muller HF, Sjuts H, Gottig S, Koenigs A, Pos KM, Pogoryelov D, Proschak E.” Approved Drugs Containing Thiols as Inhibitors of Metallo-β-lactamases: Strategy To Combat Multidrug-Resistant Bacteria”.  J. Med. Chem.201558 (8), pp 3626–3630 doi: 10.1021/jm501844d

Van den Berg, Bhamidimarri SP, Winterhalter M. “Crystal structure of a COG4313 outer membrane channel”Sci Rep. 2015 Jul 7;5:11927. doi: 10.1038/srep11927

Van den Berg B, Prathyusha Bhamidimarri S, Dahyabhai Prajapati J, Kleinekathöfer U, & Winterhalter M. “Outer-membrane translocation of bulky small molecules by passive diffusion“.Proc Natl Acad Sci U S A. 2015 Jun 9;112(23):E2991-9. Epub 2015 May 26. doi: 10.1073/pnas.1424835112

Silvia Acosta-Gutiérrez, Mariano Andrea Scorciapino, Igor Bodrenko, and Matteo Ceccarelli. “Filtering with Electric Field: The Case of E. coli Porins”.  J. Phys. Chem. Lett.20156 (10), pp 1807–1812. doi10.1021/acs.jpclett.5b00612

Kovácsová, G., Gustavsson, E., Wang, J., Kreir, M., Peuker, S., & Westenhoff, S. (2015). “Cell-free expression of a functional pore-only sodium channel”. Protein Expr Purif. 2015 Jul;111:42-7. Epub 2015 Mar 11. doi: 10.1016/j.pep.2015.03.002

Weichbrodt C1Bajaj HBaaken GWang JGuinot SKreir MBehrends JCWinterhalter MFertig N. “Antibiotic translocation through porins studied in planar lipid bilayers using parallel platforms” . Analyst. 2015 Jul 21;140(14):4874-81. Epub 2015 Apr 2. doi: 10.1039/c4an02335h